The Vielight Pocket Miracle is used for hair restoration, wound healing, pain reduction and skin rejuvenation.
Vielight researchers used a decade of research into low lever laser therapy and devised a handheld unit with maximized usage of low level lasers. They did this by encasing the most optimal wavelength into a small, portable unit with multiple adapters for multiple uses.
Below you can find out how it works for four issues: pain relief, hair restoration, skin rejuvenation, and wound healing. See the Details tab for references for each section. After taking into account all of these, you can see how the Pocket Miracle can be used for a variety of purposes.
There are two mechanisms: anti-inflammatory and analgesia. Anti-inflammatory processes occur due to reduced oxidative stress. The wavelength, when applied to injuries, is absorbed by cytochrome c oxidase. This displaces nitric oxides, which increases ATP production and reduces inflammation. Analgesia occurs when low level lasers create a nerve block, disrupting pain signals.
What about migraines? Migraines come about due to a neurovascular disorder and do not involve nerves for pain receptors. The formation of migraines involves the trigemino-cerebrovascular system. This is a pain control system in the brain which supplies sensory nerve fibers to the brain's outermost layers. Low level lasers create a vasodilation state by activiating the nitric oxide path, increasing oxygen and blood flow to the brain. This can mitigate migraine symptoms.
By irradiating the scalp, lasers stimulate growth factors that aid circulation and hair growth. This can help stop and reverse thinning of the hair. Low level lasers may help stimulate hair regrowth using the neurotrophin receptor p75(NTRp75) signalling system, and the nerve growth factor (NGF). It's been shown that NGF can promote hair growth through the transforming tyrokinase protein(TrkA).
Lasers have been found to be effective for improving skin laxity and wrinkles. As we age, we lose elasticity. Molecular-level and histologic features include fragmentation of collagen fibers, reduction in collagen, upregulation of matrix metalloproteinases(MMP), elastotic degeneration of elastic fibers, atrophy and disorientation of the epidermis, and dilated and tortuous dermal vessels.
Low Level Lasers have been proven scientifically to increase collagen, procollagen and basic fibroblast growth factor production. It also helps proliferation of fibroblasts.
Lasers are also known to increase vascular perfusion in the skin, increase microcirculation, change transforming growth factor (TGF-1) and platelet-derived growth factor (PDGF) expressions, and inhibit apoptosis.
Positive ultrastructural and histologic changes have been observed after combining 633 nm and 830 nm LED phototherapy. Alterations in the status of tissue inhibiting matrix metalloproteinases(TIMPs) and MMPs have also been shown.
The following were increased after the use of LED phototherapy: mRNA levels of interleukin(IL)-1, intercellular adhesion molecule(ICAM-1), tumor necrosis factor(TNF-), and connexin. Levels of interleukin(IL)-6 decreased.
Later, increases in the amounts of TIMPs may help protect new collagen from the proteolytic degradation of MMPs. Also, the increased connexin expression might enhance cell-to-cell communication across dermal components, especially fibroblasts. This may enhance cell responses to the effects of LED treatment, producing more collagen over a larger area, even non-exposed areas.
There are studies available (see the Details tab). In one, 300 patients were given LED therapy in the 590 nm range alone while 600 received LED treatments combined with a photorejuvenation procedure that was thermal-based. Out of the group who received LED alone, 90% reported skin texture softening and a reduction in fine lines and roughness, ranging from subtle to significant changes.
Another study used different pulse sequence parameters in a multicenter trial. 90 patients, over four weeks, received eight LED treatments. Very favorable results were shown, with 90% improving by at least one photoaging category and 65% showing an improvement in fine lines, facial texture, pigmentation and background erythema. Results peaked at four to six months after completion. Common findings included marked increase in collagen in the papillary dermis and a reduction in MMP-1.
A study by Barolet et al is consistent with those mentioned previously. A 3D model was used of tissue-engineered reconstructed human skin to investigate how a 660-nm, 50-mW/cm, 4-J/cm2 LED could modulate MMP-1 and collagen. Results showed downregulation of MMP-1 and upregulation of collagen.
A single-blind split face clinical study assessed the results of the treatment on appearance and skin texture of people with photoaged/aged skin using 12 treatments. 90% of people had a reduction in surface roughness and rhytid depth. 87% reported a reduction in the Fitzpatrick wrinkling severity score.
Low level laser therapy has been shown to speed up healing in post-surgical and traumatic wounds. It also helps against keloid formation and hypertrophic scarring.
The top cells of importance in healing of wounds are macrophages, leukocytes and mast cells (inflammatory response), epidermal basal layer keratinocytes (makes up 95% of skin structure), myofibroblasts (remodeling phase of wound healing), and fibroblasts and endetheliocytes (proliferation of cells). The three stages of healing are inflammation, proliferation and remodeling.
After three decades of studies, research shows involved mechanisms occur at subcellular and cellular levels and are dependent on wavelength. The wavelengths that stand out are 633 nm and 830 nm.
Both are shown to activate mother keratinocytes that synthesize useful cytokines that enter the dermis and help cellular processes and maintaining matrix homeostasis.
An experiment shows an increase in local blood circulation around the wound, caused by treatment with a 830 nm laser, increased the likelihood of positive flap survival on mice. A significantly better survival correlated with increased perfusion in the area treated by the laser.
Increased blood flow improves oxygen and nutrient flow to the area. Higher oxygen tension forms multiple gradients between the surrounding tissue and the damaged area, connecting reparation cells.
- Light source: Low level laser
- Wavelength: 655 nm
- Color: Red
- Pulse mode: Continuous
- Battery Life: Two months
- Safety issues: Avoid contact with eyes, may result in damage
- Warranty: one year
- Comes with adapters for use with hair regrowth, pain relief, skin and wound healing, as well as a positioning strap.
Pain Relief References
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- Calderhead, R. G. (2013). Photobiological Basics of Photosurgery and Phototherapy. South Korea: Hanmi Medical Publishing Co.
- Chow, R. T., Johnson, M., Lopes-Martin, R., & Bjordal, J. (2009). Efficacy Of Low-Level Laser Therapy In The Treatment Of Neck Pain. http://www.medicalnewstoday.com/articles/170796.php.
- Hagiwara, S., Iwasaka, H., Okuda, K., & Noguchi, T. (2007). GaAlAs (830 nm) low-level laser enhances peripheral endogenous opioid analgesia in rats. PubMed
- Hamblin, M., & Demidova, T. (2006). Mechanisms of Low Level Light Therapy.
- Hinz, B. (2007). Formation and function of the myofibroblast during tissue repair. PubMed
- Hopkins, J., McLoda, T., Seegmiller, J., & Baxter, D. (2004). Low-Level Laser Therapy Facilitates Superficial Wound Healing in Humans: A Triple-Blind, Sham-Controlled Study. PubMed
- Hospital, S. J. (2007, June 3). Science Daily. Retrieved Jan 7, 2014, from Science Daily: http://www.sciencedaily.com/releases/2007/06/070601152207.htm
- Karu, T., Kalendo, G. S., Letokhov, V. S., & Lobko, V. V. (1982). Biostimulation of HeLa cells by low-intensity visible light.
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- Link, A. S., Kuris, A., & Edvinsson, L. (2007). Treatment of migraine attacks based on the interaction with the trigemino-cerebrovascular system. PubMed
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- Yu, H., Chang, K., Yu, C., Chen, J., & Chen, G. (1996). Low-energy helium-neon laser irradiation stimulates interleukin-1 alpha and interleukin-8 release from cultured human keratinocytes. PubMed
Hair Restoration References
- E.M. Peters, S. Hendrix, G. Golz, B.F. Klapp, P.C. Arck and R. Paus, Nerve Growth Factor and Its Precursor Differentially Regulate Hair Cycle Progression in Mice, J Histochem Cytochem (2005).
- V.A. Botchkarev, N.V. Botchkareva, K.M. Albers, L.H. Chen, P. Welker and R. Paus, A role for p75 neurotrophin receptor in the control of apoptosis-driven hair follicle regression, Faseb J 14 (2000) 1931-42.
- F. Schwartz, C. Brodie, E. Appel, G. Kazimirsky and A.Shainberg, Effect of helium/neon laser irradiation on nerve growth factor synthesis and secretion in skeletal muscle cultures, J Photochem Photobiol B 66 (2002) 195-200.
Skin Rejuvenation References
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- Weiss RA, McDaniel DH, Geronemus RG, et al. Clinical experience with light-emitting diode (LED) photomodulation. Dermatol Surg. 2005;31:1199-1205.
- Weiss RA, McDaniel DH, Geronemus RG, et al. Clinical trial of a novel non-thermal LED array for reversal of photoaging: Clinical, histologic, and surface profilometric results. Lasers Surg Med. 2005;36:85-91.
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- Russell BA, Kellett N, Reilly LR. A study to determine the efficacy of combination LED light therapy (633 nm and 830 nm) in facial skin rejuvenation. J Cosmet Laser Ther. 2005;7:196-200.
- Barolet D, Roberge CJ, Auger FA, et al. Regulation of skin collagen metabolism in vitro using a pulsed 660 nm LED light source: Clinical correlation with a single-blinded study. J Invest Dermatol. 2009;129:2751-2759.
- Abergel RP, Lyons RF, Castel JC, et al. Biostimulation of wound healing by lasers: Experimental approaches in animal models and in fibroblast cultures. J Dermatol Surg Oncol. 1987;13:127-133.
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- Schindl A, Heinze G, Schindl M, et al. Systemic effects of low-intensity laser irradiation on skin microcirculation in patients with diabetic microangiopathy. Microvasc Res. 2002;64:240-246.
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- Kucuk BB, oral K, Selcuk NA, et al. The anti-inflammatory effect of low-level laser therapy on experimentally induced inflammation of rabbit temporomandibular joint retrodiscal tissues. J Orofac Pain. 2010;24:293-297.
- Geronemus RG, Weiss RA, Weiss MA, et al. Non-ablative LED photomodulation light activated fibroblast stimulation clinical trial. Lasers Surg Med. 2003;25:22.
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- Lee SY, Park KH, Choi JW, et al. A prospective, randomized, placebocontrolled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: Clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings. J Photochem Photobiol B Biol.2007;88:51-67.
Wound Care References
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- Calderhead, R., Kubota, J., Trelles, M., & Ohshiro, T. (2008). One mechanism behind LED phototherapy for wound healing and skin rejuvenation: key role of the mast cell. Laser Therapy, 17 , 141-148.
- Karu, T. (2007). Ten Lectures on Basic Science of Laser Phototherapy. Prima Books AB
- Kubota, J. (2004). Defocused diode laser therapy (830 nm) in the treatment of unresponsive skin ulcers: a preliminary trial. J Cosmet Laser Therapy, 6 , 96-102.
- Kubota, J. (2004). Effects of diode laser therapy on blood flow in axial patter flaps in the rat model. Lasers Med Sci, 17 , 146-153.
- McLoda, T. A., Hopkins, J. T., Seegmiller, J. G., & Baxter, G. D. (2004). Low-Level Laser Therapy Facilitates Superficial Wound Healing in Humans: A Triple-Blind, Sham-Controlled Study. J Athl Train(PubMed) , 223-229.
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- Trelles, M., Rigau, J., & Velez, M. (2002). LLLT in vivo effects on mast cells. Simunovic Z (Ed) Lasers in Medicine and Dentistry(Part 1), Laser Medico, Switzerland , 169-186.
- Zhevago, N., & KA, S. (2006). Proand anti-inflammatory cytokine content in human peripheral blood after its transcutaneous(in vovo) and direct(in vitro) irradiation with polychromatic visible and infrared light. Photomed Laser Surgery , 123-139.